NMN and NAD+
What is NMN and NAD+?
NAD+Helps Control DNA Damage
What is NMN and NAD+?
NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+)and is considered a key component to increases NAD+ levels in cells
What does NAD+ Do?
NAD+Helps Control DNA Damage
What is NMN and NAD+?
NAD+ is the most abundant molecule in the body besides water, and without it, an organism would die. NAD+ is used by many proteins throughout the body, such as the sirtuins, which repair damaged DNA. It is also important for mitochondria, which are the powerhouses of the cell and generate the chemical energy that our boides use.
NAD+Helps Control DNA Damage
NAD+Helps Control DNA Damage
NAD+Helps Control DNA Damage
As organisms grow older, they accrue DNA damage due to environmental factors such as radiation, pollution, and imprecise DNA replication. According to the current aging theory, the accumulation of DNA damage is the main cause of aging. Almost all cells contain the 'molecule machinery' to repair this damage. This machinery consumes NAD+
As organisms grow older, they accrue DNA damage due to environmental factors such as radiation, pollution, and imprecise DNA replication. According to the current aging theory, the accumulation of DNA damage is the main cause of aging. Almost all cells contain the 'molecule machinery' to repair this damage. This machinery consumes NAD+ and energy molecules. Therefore, excessive DNA damage can drain valuable cellular resources.
One important DNA repair protien, PARP (Poly(ADP-ribose)polymerase), depends on NAD+ to function. Older individuals experience decreased levels of NAD+. The accumulation of DNA damage as a result of the normal again process leads to increased PARP, which causes decreased NAD+ concentration. This depletion is exacerbated by any further DNA damage in the mitochondria.